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目的探讨中青年阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者与颈动脉及下肢动脉粥样硬化斑块之间的关系。方法将应用多导睡眠监测仪(PSG)诊断的110例OSAHS患者分成轻度组(36例)、中度组(38例)、重度组(36例),另设36名健康体检者作为对照组,所有入选者行颈动脉和下肢动脉彩色多普勒超声检测。结果OSAHS患者颈动脉和(或)下肢动脉粥样硬化斑块检出率明显高于对照组(P<0.01),且随着病情加重斑块的发生率有增加的趋势,而且在OSAHS各亚组间下肢动脉粥样硬化斑块的检出率显著高于颈动脉粥样硬化斑块检出率(P<0.01)。结论颈动脉和下肢动脉粥样硬化斑块与OSAHS密切相关,应引起高度重视。
Objective To explore the relationship between young and middle-aged patients with obstructive sleep apnea-hypopnea syndrome (OSAHS) and carotid and lower extremity atherosclerotic plaques. Methods One hundred and ten OSAHS patients diagnosed by polysomnography (PSG) were divided into mild group (36 cases), moderate group (38 cases) and severe group (36 cases), and another 36 healthy subjects as control Group, all candidates underwent carotid artery and lower extremity arterial color Doppler ultrasound examination. Results The detection rate of atherosclerotic plaque in carotid artery and / or lower extremity in OSAHS patients was significantly higher than that in control group (P <0.01), and plaque incidence increased with the progression of OSAHS. The detection rate of atherosclerotic plaques in the lower limbs was significantly higher than that in the carotid atherosclerosis plaques (P <0.01). Conclusions Carotid artery and lower extremity atherosclerotic plaques are closely related to OSAHS and should be given high priority.