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目的:探讨脑脊液置换联合腰椎置管连续给药对结核性脑膜炎患者脑脊液指标的影响;方法:将60例重症结核性脑膜炎患者随机分为两组,对照组常规腰椎穿刺并给予抗结核药物及激素药物治疗;治疗组在此基础上,采用脑脊液置换联合腰椎置管连续椎管给药治疗。比较两组患者治疗后脑脊液指标、治愈率和平均住院天数的变化。结果:治疗组患者脑脊液蛋白含量较对照组明显降低,治疗组治愈率(93.33%)与对照组治愈率(73.33%)相比具有显著性差异(P<0.05)。结论:采用脑脊液置换联合椎管内持续给药治疗重症结核性脑膜炎可迅速降低脑脊液蛋白含量并提高治愈率。
Objective: To investigate the effect of cerebrospinal fluid replacement combined with continuous lumbar catheterization on cerebrospinal fluid (CSF) in patients with tuberculous meningitis.Methods: Sixty patients with severe tuberculous meningitis were randomly divided into two groups. The control group received conventional lumbar puncture and anti-tuberculosis drugs And hormone therapy. On the basis of this, the treatment group was treated with continuous replacement of cerebrospinal fluid and lumbar spinal canal. The changes of cerebrospinal fluid (CSF), cure rate and average length of hospital stay after treatment were compared between the two groups. Results: The content of cerebrospinal fluid in treatment group was significantly lower than that in control group. The cure rate in treatment group (93.33%) was significantly lower than that in control group (73.33%) (P <0.05). Conclusion: The treatment of severe tuberculous meningitis by cerebrospinal fluid replacement and intraspinal continuous administration can rapidly reduce the protein content of cerebrospinal fluid and improve the cure rate.