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目的 为了观察超氧化物歧化酶 (SOD)及丙二醛 (MDA)在新生儿缺氧缺血性脑病 (HIE)中的变化 ,以探讨新生儿HIE与氧自由基 (OFR)的关系。方法 对收住的 1 5例中重度HIE患儿检测治疗前后血清SOD活性及脂质过氧化反应产物MDA含量。结果 新生儿HIE患儿极期SOD活性明显较恢复期降低 (P <0 .0 1 ) ,MDA含量明显升高(P <0 .0 1 ) ,而恢复期SOD活性升高 ,MDA含量下降。结论 新生儿HIE极期抗氧化功能下降 ,清除氧自由基的能力降低 ,脂质过氧化物增多 ,提示氧自由基参与HIE脑损伤的病理过程 ,为HIE治疗中应用氧自由基清除剂提供重要依据 ,同时测定SOD ,MDA也可作为疾病转归的监测手段之一
Objective To investigate the changes of superoxide dismutase (SOD) and malondialdehyde (MDA) in neonates with hypoxic-ischemic encephalopathy (HIE) in order to investigate the relationship between neonatal HIE and oxygen free radicals (OFR). Methods Serum SOD activity and lipid peroxidation product (MDA) content were measured before and after treatment in 15 moderate-severe HIE infants admitted to hospital. Results The activity of superoxide dismutase (SOD) in neonates with HIE was significantly lower than that in convalescence (P <0.01), and the content of MDA was significantly increased (P <0.01). However, the activity of SOD was increased and the content of MDA decreased during recovery. Conclusions The neonatal HIE has declining anti-oxidant function during the polar phase, reducing the ability of scavenging oxygen free radicals and increasing lipid peroxides, suggesting that oxygen free radicals participate in the pathological process of HIE brain injury and provide important information for the application of oxygen radical scavengers in HIE treatment Based on the determination of SOD, MDA can also be used as a means of monitoring the outcome of the disease