In this work a system which consists of chitosan microcores entrapped in ethylcellulose is presented.Vitamin D2 was efficiently entrapped in chitosan microcores with spray-drying method and was microencapsulatedby coating of ethylcellulose. The average size of chitosan microspheres was 6.06 μm. The morphology and releaseproperties of microcapsules were tested. The results of release in vitro showed that the microcapsule could realizesustained release for 12 h in artificial intestinal juice.