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杂种犬１１只，快速股动脉放血使其平均动脉压（ＭＡＰ）达６．０ｋＰａ左右，维持９０ｍｉｎ后输回全部血液，观察２４０ｍｉｎ。维拉帕米（Ｖｅｒａｐａｍｉｌ，Ｖｅｒ）组于休克３０ｍｉｎ时静脉输注Ｖｅｒ１５０μｇ／ｋｇ，１５ｍｉｎ内输毕。实验结果发现，Ｖｅｒ治疗后，ＭＡＰ高于休克组，在休克２４０ｍｉｎ时两组差异有显著性。Ｖｅｒ治疗还可以降低胰腺组织黄嘌呤氧化酶（ＸＯ）活性，减少脂质过氧化产物丙二醛（ＭＤＡ）含量，提高超氧化物歧化酶（ＳＯＤ）和谷胱甘肽过氧化物酶（ＧＳＨ－ｐｘ）活性。并能减轻胰腺组织的线粒体和内质网损伤。提示Ｖｅｒ对失血性休克犬的胰腺具有保护作用。
11 hybrid dogs, rapid femoral artery bleeding so that the mean arterial pressure (MAP) of about 6.0kPa, maintained 90min after the return of all blood, observed 240min. Verapamil (Ver) group received intravenous infusion of Ver150μg / kg 30min after shock, and the infusion was completed within 15min. The experimental results showed that after the treatment with Ver, MAP was higher than that in shock group, and there was significant difference between the two groups at 240min after shock. Treatment with Ver also reduced xanthine oxidase (XO) activity, reduced lipid peroxidation product malondialdehyde (MDA) content, increased superoxide dismutase (SOD) and glutathione peroxidase (GSH) -px) activity. And can reduce pancreatic mitochondria and endoplasmic reticulum damage. Tip Ver on hemorrhagic shock in dogs with pancreatic protective effect.