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构建恰当的动物模型是开展骨质疏松症(osteoporosis,OP)病因、病理生理研究和药物治疗的关键。因不同类型OP的成因、病理生理变化各有特点,故建模方法亦不同。本文针对OP模型动物的选择、不同的造模方法及相关进展进行综述。1造模动物Rodgers等[1]指出理想的动物模型应有如下3个特点:(1)方便性;(2)关联性:与人体条件相接近;(3)适宜性:研究某一特定问题,最好用特定的
Establishing a proper animal model is the key to carry out the etiology, pathophysiology and drug treatment of osteoporosis (OP). Due to the different types of OP causes, pathophysiological changes have their own characteristics, so modeling methods are also different. This article reviews the selection of OP model animals, different modeling methods and related progress. 1 Modeling animal Rodgers et al [1] pointed out that the ideal animal model should have the following three characteristics: (1) convenience; (2) relevance: close to the human condition; (3) suitability: to study a particular problem , It is best to use specific