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目的研究白花碎米荠Cardamine leucantha的化学成分。方法采用硅胶、聚酰胺、D-101大孔吸附树脂、凝胶柱色谱等方法对白花碎米荠乙醇提取物进行分离纯化,并根据理化性质和波谱数据对化合物进行结构鉴定。结果从白花碎米荠乙醇提取物中分离鉴定了14个化合物,其中包括3个简单吲哚类化合物:吲哚-3-甲酸(1)、6-羟基吲哚-3-甲酸(2)、吲哚-3-甲酸-6-O-β-D-葡萄糖苷(3);2个香豆素类化合物:七叶内酯(4)、七叶苷(5);7个甾醇类化合物:3-O-(p-香豆酰基)-β-谷甾醇(6)、β-谷甾醇(7)、5α,8α-过氧麦角甾-6,22-二烯-3β-醇(8)、5α,8α-过氧麦角甾-6,9(11),22-三烯-3β-醇(9)、7α-羟基-β-谷甾醇(10)、6′-O-棕榈酰-β-胡萝卜苷(11)、胡萝卜苷(12);2个酚类化合物:对羟基苯甲酸(13)、香草酸(14)。结论所有化合物均为首次从该属植物中分离得到。
Objective To study the chemical constituents of Cardamine leucantha. Methods Silica gel, polyamide, D-101 macroporous resin and gel column chromatography were used to separate and purify the ethanol extract of Camellia, and their chemical structures were elucidated on the basis of physico-chemical properties and spectral data. Results Fourteen compounds were isolated and identified from the ethanol extract of Camellia chinensis, including three simple indoles: indole-3-carboxylic acid (1), 6-hydroxyindole- (3); 2 coumarins: aesculetin (4), esculin (5); 7 sterol compounds: 6-O-β- 3-O- (p-coumaroyl) -β-sitosterol (6), β-sitosterol (7), 5a, 8a- (10), 6’-O-palmitoyl-β (5α, 8α-peroxynicotine-6,9 - daucosterol (11), daucosterol (12); two phenolic compounds: p-hydroxybenzoic acid (13), vanillic acid (14). Conclusion All the compounds were isolated from this genus for the first time.