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以4-氨基-5-(3,4,5-三甲氧基苯基)-3-巯基-1,2,4-三唑为原料,环化得到6-巯基-3-(3,4,5-三甲氧基苯基)-1,2,4-三唑[3,4-b][1,3,4]噻二唑再与取代苄氯反应,得到9个6-取代苄硫基-3-(3,4,5-三甲氧基苯基)-1,2,4-三唑[3,4-b][1,3,4]噻二唑类衍生物3a～3i.其结构经IR,1H NMR,MS和元素分析确证.初步生物活性测试结果表明部分化合物有一定的杀菌活性.
Starting from 4-amino-5- (3,4,5-trimethoxyphenyl) -3-mercapto-1,2,4-triazole, cyclization gave 6-mercapto-3- Trimethoxyphenyl) -1,2,4-triazolo [3,4-b] [1,3,4] thiadiazoles are reacted with substituted benzyl chloride to give 9 6-substituted benzylthio groups (3,4,5-trimethoxyphenyl) -1,2,4-triazolo [3,4-b] [1,3,4] thiadiazole derivatives 3a to 3i The structures were confirmed by IR, 1H NMR, MS and elemental analysis.The preliminary bioassay results indicated that some of the compounds had some bactericidal activity.