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目的:探讨川崎病患儿恢复晚期颈动脉内膜-中膜厚度变化与高敏C-反应蛋白(hs-CRP)水平的相关性,为防治川崎病的血管病变提供科学依据。方法:将2009年1月至2011年12月在我院门诊随访的127例川崎病恢复晚期患儿用彩色多普勒超声检测颈动脉内膜-中层厚度(IMT)和粥样硬化斑块的发生情况,采用ELISA的方法测定hs-CRP。结果:冠状动脉病变组的颈动脉内膜-中膜厚度和hs-CRP水平明显高于冠状动脉正常组和正常对照组。结论:监测颈动脉内膜-中膜厚度变化与hs-CRP水平对评价川崎病恢复晚期血管病变的预后具有重要意义。
Objective: To investigate the relationship between the changes of carotid intima-media thickness and the level of hs-CRP in children with Kawasaki disease and to provide a scientific basis for the prevention and treatment of Kawasaki disease. Methods: From January 2009 to December 2011, 127 children with Kawasaki disease who were followed up in our hospital were examined with color Doppler ultrasonography to detect carotid intima - media thickness (IMT) and atherosclerotic plaque Hs-CRP was measured by ELISA. Results: The carotid intima-media thickness and hs-CRP level in coronary artery disease group were significantly higher than those in normal coronary artery group and normal control group. CONCLUSION: Monitoring the intima-media thickness of carotid artery and the level of hs-CRP are of great significance in evaluating the prognosis of Kawasaki disease in the recovery of advanced vascular disease.