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目的探讨脂蛋白(a)[Lp(a)]与冠状动脉病变程度的关系。方法经冠状动脉造影检查确诊冠心病患者370例,根据Gensini积分分为冠心病轻度组(<30分,146例)、中度组(30~60分,127例)和重度组(>60分,97例)。冠状动脉造影正常的49例非冠心病患者作为对照组。比较各组血清Lp(a)水平,分析其与Gensini积分的相关性。结果冠心病轻度、中度和重度组Lp(a)水平均高于对照组[(168.84±52.72)mg/L、(310.32±143.80)mg/L和(373.52±169.49)mg/L vs.(73.84±38.44)mg/L](P<0.05);重度组Lp(a)水平高于中度组,中度组高于轻度组(P<0.05)。冠心病患者血清Lp(a)水平与Gensini积分呈正相关(r=0.578,P<0.05)。结论冠心病患者血清Lp(a)水平随着冠状动脉病变程度加重而升高。
Objective To investigate the relationship between lipoprotein (a) [Lp (a)] and the severity of coronary artery disease. Methods A total of 370 CHD patients diagnosed by coronary angiography were divided into mild coronary heart disease group (<30 points, 146 cases), moderate group (30-60 points, 127 cases) and severe coronary heart disease group (> 60 cases) Points, 97 cases). 49 cases of non-coronary heart disease normal coronary angiography as a control group. The levels of serum Lp (a) in each group were compared and their correlations with Gensini scores were analyzed. Results The levels of Lp (a) in mild, moderate and severe coronary heart disease were significantly higher than those in the control group [(168.84 ± 52.72) mg / L, (310.32 ± 143.80) mg / L and (373.52 ± 169.49) mg / L vs. (73.84 ± 38.44) mg / L] (P <0.05). The levels of Lp (a) in severe group were higher than those in moderate group and those in moderate group were higher than those in mild group (P <0.05). Serum Lp (a) level in patients with coronary heart disease was positively correlated with Gensini score (r = 0.578, P <0.05). Conclusion Serum Lp (a) levels in patients with coronary heart disease increased with the severity of coronary artery disease.