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霉酚酸酯(MMF)是一种新型免疫抑制剂,其主要作用机理是非竞争性、可逆性抑制嘌呤核苷酸经典合成途径的限速酶次黄嘌呤单核苷酸脱氢酶的活性,从而抑制淋巴细胞的增殖。MMF已广泛应用于实体器官移植,可明显减少急性排斥的发生率及严重程度,提高移植的成功率。最近,MMF开始应用于造血干细胞移植后移植物抗宿主病(GVHD)的防治,初步疗效令人满意。本文就MMF防治GVHD的作用机理、动物实验及临床研究作一综述。
Mycophenolate mofetil (MMF) is a novel immunosuppressant whose main mechanism of action is noncompetitive and reversibly inhibits the rate-limiting enzyme hypoxanthine mononucleotide dehydrogenase activity of the classical purine synthesis pathway, Thereby inhibiting the proliferation of lymphocytes. MMF has been widely used in solid organ transplantation, can significantly reduce the incidence and severity of acute rejection, improve the success rate of transplantation. Recently, MMF began to be used in the prevention and treatment of graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation, and the initial therapeutic effect was satisfactory. This article reviews the mechanism of MMF in the prevention and treatment of GVHD, animal experiments and clinical studies.