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目的 探讨热休克蛋白 70 (HSP70 )在肝细胞癌 (HCC)中的表达及其意义。方法 采用免疫组化技术对 4 4例HCC和癌旁组织中HSP70的表达进行检测。结果 HCC中HSP70阳性率明显高于癌旁组织 (阳性率分别为 6 8.2 %和2 7.3% ,χ2 =7.3,P <0 .0 1)。HSP70表达与癌周淋巴细胞浸润 (χ2 =3.2 ,P >0 .0 5 )和转移 (χ2 =2 .3,P >0 .0 5 )无关 ,但与癌组织分化程度有关 (χ2 =4 .5 ,P <0 .0 5 )。结论 HSP70的异常表达与HCC的发生、发展有关 ,且可能是HCC发展、恶化的重要标志
Objective To investigate the expression and significance of heat shock protein 70 (HSP70) in hepatocellular carcinoma (HCC). Methods Immunohistochemistry was used to detect the expression of HSP70 in 44 cases of HCC and adjacent tissues. Results The positive rate of HSP70 in HCC was significantly higher than that in paracancerous tissues (positive rates were 68.2% and 27.3%, respectively, χ2 = 7.3, P < 0.01). HSP70 expression was not associated with lymphocytic infiltration (χ2=3.2, P>0.05) and metastasis (χ2=2.3, P>0.05), but was related to the degree of differentiation of cancer (χ2=4. 5, P <0. 0 5 ). Conclusion The abnormal expression of HSP70 is related to the occurrence and development of HCC, and may be an important indicator of the development and progression of HCC.