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目的 探索早期预防维生素K缺乏性出血的有效途径。方法 通过孕妇口服维生素K1,观察能否改善其新生儿的维生素K营养状况。结果 对照组新生儿骨钙蛋白未羧化率高于维生素K组 (6 6 6 6 %± 18 2 0 %和 13 41%± 11 96 % ,P <0 ,0 0 1)。对照组新生儿PIVKA -Ⅱ的阳性率为 2 6 45 % ,而维生素K组PIVKA -Ⅱ阳性率降至 0 % (P <0 0 0 1)。结论让孕妇在分娩后期服用维生素K1可使其新生儿的维生素K营养状况得以改善 ,孕妇口服维生素K1是早期预防维生素K缺乏性出血的新途径。
Objective To explore an effective way to prevent vitamin K deficiency bleeding in early stage. Methods Vitamin K1 was orally administered to pregnant women to observe whether vitamin K nutrition could be improved in neonates. Results In the control group, the rate of non-carboxylation of osteocalcin in neonates was higher than that of vitamin K group (666 ± 18 20% and 13 41% ± 11 96%, P <0,01). The positive rate of PIVKA-Ⅱ in control group was 2645%, while the positive rate of PIVKA-Ⅱ in vitamin K group was reduced to 0% (P <0.01). Conclusions Pregnant women taking vitamin K1 in the later part of delivery can improve the vitamin K nutrition status of their newborns. The oral administration of vitamin K1 in pregnant women is a new way to prevent vitamin K deficiency bleeding in early stage.