论文部分内容阅读
目的：探讨地尔硫卓（Ｄｉｌｔｉａｚｅｍ，Ｄｉｌ）对失血性休克犬肾脏的保护作用及机理。方法：动脉放血，使血压降低至５３３～６６７ｋＰａ（４０～５０ｍｍＨｇ），维持９０ｍｉｎ后回输血液进行复苏。在休克３０ｍｉｎ时，分别给动物输注盐水和（或）Ｄｉｌ。结果：Ｄｉｌ能明显提高失血性休克动物的平均动脉压（ＭＡＰ）；降低肾脏组织中的丙二醛（ＭＤＡ）含量和超氧化物歧化酶（ＳＯＤ）的活性；保护肾脏组织的超微结构。结论：Ｄｉｌ对失血性休克犬的肾脏具有保护作用。
Objective: To investigate the protective effect and mechanism of Diltiazem (Dil) on the kidney of hemorrhagic shock dogs. Methods: Artery bleeding, blood pressure was reduced to 5 33 ~ 6 67kPa (40 ~ 50mmHg), 90min after the return of blood for resuscitation. At 30 min of shock, the animals were respectively infused with saline and / or Dil. RESULTS: Dil significantly increased mean arterial pressure (MAP) in hemorrhagic shock animals, decreased MDA content and superoxide dismutase (SOD) activity in renal tissues, and protected renal tissue ultrastructure. Conclusion: Dil has a protective effect on the kidneys of hemorrhagic shock dogs.