论文部分内容阅读
目的:探讨密集方案新辅助化疗临床效果及对乳腺癌细胞凋亡的影响。方法:44例乳腺癌患者随机分成CEF14组和CEF21组,分别接受CEF14方案和CEF21方案新辅助化疗,观察其临床结果;使用TUNEL法观察各组标本化疗前后细胞凋亡指数,以分析不同密度化疗方案对乳腺癌细胞凋亡的影响。结果:最终35例完成了既定方案化疗,CEF14组临床有效率为50.00%(9/18),CEF21组临床有效率为41.18%(7/17)(P>0.05)。CEF14组、CEF21组化疗前凋亡指数分别为(6.36±1.05)、(7.40±3.93)(P>0.05);化疗后分别为(24.00±12.00)、(17.52±7.00)(P>0.05),两组化疗前后比较均有统计学意义(P<0.05)。结论:密集方案新辅助化疗与常规方案新辅助化疗有相似的临床效果,均能诱导肿瘤细胞的凋亡增加。
Objective: To investigate the clinical effect of neoadjuvant chemotherapy with intensive chemotherapy and its effect on the apoptosis of breast cancer cells. Methods: Forty-four patients with breast cancer were randomly divided into CEF14 group and CEF21 group, received CEF14 regimen and CEF21 regimen neoadjuvant chemotherapy, respectively. The clinical results were observed. TUNEL method was used to observe the apoptosis index of each group before and after chemotherapy to analyze the effect of different density chemotherapy Program on breast cancer cell apoptosis. Results: The final regimen regimen was completed in 35 cases. The clinical efficacy rate was 50.00% (9/18) in CEF14 group and 41.18% (7/17) in CEF21 group (P> 0.05). The apoptosis index of CEF14 group and CEF21 group were (6.36 ± 1.05) and (7.40 ± 3.93), respectively (P <0.05), and were 24.00 ± 12.00 and 17.52 ± 7.00 respectively after chemotherapy (P> 0.05) The two groups before and after chemotherapy were statistically significant (P <0.05). Conclusion: The neoadjuvant chemotherapy with intensive regimens has similar clinical effects with neoadjuvant chemotherapy of conventional regimens, and all of them can induce the apoptosis of tumor cells to increase.