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脂质过氧化是发生在不饱和脂酸中的自由基反应,它和许多生理与病理过程有关,既用来阐明一些正常生命活动,也用来解释某些疾病的发生和发展过程,近年研究证明,实验性矽肺的脂质过氧化物含量增加,并试图用自由基反应解释矽肺的发病机理,随着分子生物学的进展,自由基的研究越来越深入,其在矽肺发病过程的作用也日趋重要。本文扼要介绍脂质过氧化物的形成及其引起的损害,探讨脂质过氧化与矽肺发病的关系,并就自由基反应和矽肺防治药物的问题加以综述。
Lipid peroxidation is a free radical reaction occurs in unsaturated fatty acids, and it is related to many physiological and pathological processes, both to illustrate some of the normal life activities, but also to explain the occurrence and development of certain diseases, recent studies Proved that the experimental silicosis of lipid peroxides increased, and attempts to explain the pathogenesis of silicosis with free radical reactions, with the progress of molecular biology, more and more free radical research, its role in the pathogenesis of silicosis It is also increasingly important. This article briefly describes the formation of lipid peroxides and the damage they cause, discusses the relationship between lipid peroxidation and silicosis, and summarizes the issues of free radical reactions and the prevention and treatment of silicosis.