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目的探讨原发性肝癌(PHC)与乙、丙肝炎病毒感染的关系。方法HBsAg、抗-HBs、HBeAg测定用放射免疫法;抗-HBe、抗-HBc、AFP测定用酶联免疫法;HBV、DNA检测采用PCR法;抗HCV采用ELISA法。结果肝癌患者血清HBVDNA、HCVRNA及HBVDNA、HCVRNA双阳性者各占63.89%、12.50%及15.28%。其中8.33%的肝癌患者HCV、HBV标志物均为阴性。结论原发性肝癌与HBV、HCV的感染有密切关系。
Objective To investigate the relationship between primary hepatocellular carcinoma (PHC) and hepatitis B and C virus infection. Methods HBsAg, anti-HBs and HBeAg were determined by radioimmunoassay, anti-HBe, anti-HBc and AFP by enzyme-linked immunosorbent assay (ELISA); HBV and DNA were detected by PCR; anti-HCV by ELISA. Results The serum HBVDNA, HCVRNA, HBVDNA and HCVRNA were 63.89%, 12.50% and 15.28% respectively. Among them, 8.33% of patients with liver cancer had negative HCV and HBV markers. Conclusion Primary liver cancer is closely related to the infection of HBV and HCV.