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目的:观察单用贝那普利及贝那普利联用激素对局灶节段性肾小球硬化症的疗效。方法:109例尿蛋白>1．0 g·d~(-1),血肌酐<133μmol·L~(-1)的局灶节段性肾小球硬化症患者随机分成单用组和联用组,单用组应用贝那普利10-30 mg·d~(-1)治疗,联用组应用贝那普利10～30 mg·d~(-1)+泼尼松1 mg·kg~(-1)·d~(-1)治疗,观察24 h尿蛋白定量,血白蛋白、胆固醇、肌酐的变化。结果:两组均能明显减少蛋白尿,治疗1月后尿蛋白即有显著下降(P<0．01)。两组尿蛋白减少差值及血肌酐比较差异无统计学意义(P>0．05)。结论:ACEI联用激素并不比单用ACEI治疗有更好的疗效,而单用ACEI可能为有效的治疗手段,又可避免激素的副作用。
Objective: To observe the effect of benazepril combined with benazepril alone on focal segmental glomerulosclerosis. Methods: 109 cases of focal segmental glomerulosclerosis with urinary protein> 1.0 g · d ~ (-1) and serum creatinine <133 μmol·L ~ (-1) were randomly divided into single and combined groups Group, the single use group benazepril 10-30 mg · d ~ (-1) treatment, combination group benazepril 10 ~ 30 mg · d -1 prednisone 1 mg · kg ~ (-1) · d ~ (-1) treatment, 24 h urinary protein, serum albumin, cholesterol and creatinine were observed. Results: Proteinuria was significantly reduced in both groups. Urine protein was significantly decreased after 1 month of treatment (P <0.01). There was no significant difference between the two groups in the reduction of urinary protein and serum creatinine (P> 0.05). CONCLUSION: ACEI combined with hormones is no better than ACEI alone, and ACEI alone may be an effective treatment and can avoid side effects of hormones.