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目的探讨晋、冀、豫三省交界处食管癌高发的原因;方法根据“氮循环”病因假说,结合我们在该处所做的蚕豆根尖微核实验结果,收集地理、地质、气候条件、工农业污染等资料,与沿河县、市食管癌发病率、死亡率资料(1969年~1971年调查结果,和高发点连续48年的食管癌死亡登记资料)进行对照,分析河流对食管癌发病率、死亡率的影响。结果1、山西省晋东南地区盛产无烟煤,工农业污染源较多,河流逐渐汇集了土壤包气带、污水、农肥中的N-亚硝基化合物两类前体物,浓度逐渐升高,并通过河流、地下水等迁移到中下游。2、发源于山西省晋东南地区的河流主要有六条,清漳河、浊漳河、沁河、丹河、淇河、卫河,其中前五条河流成集束状流向,卫河在5条河流的下游成圆弧状起拦截、排泄作用,使河水流向海河,卫河晋东南侧均为食管癌高发区,成不规则同心圆状分布。3、晋冀豫三省交界处,气候半干旱,多为山区、丘陵,水源奇缺,居民多有修渠引水习惯。4、人群有效污染比率越大、食管癌死亡率越高。结论晋冀豫三省交界、太行山南段大断裂处食管癌高发与河流有关。气候类型和胺类、酰胺类污染源决定了两类前体物的有效浓度。河流、人工渠网的水是载体,决定了两类前体物的分布范围。人群直接、间接饮用河水、灌溉渠水的人数多少决定了人群死亡率的大小。
Objective To investigate the causes of high incidence of esophageal cancer at the junction of Shanxi, Hebei and Henan provinces. Methods According to the “nitrogen cycle” etiology hypothesis and the results of micronucleus test of Vicia faba root tips we made here, we collected geography, geology, climatic conditions, Agricultural pollution and other data, and Yanhe County, the incidence of esophageal cancer, mortality data (1969-1971 survey results, and high incidence of 48 consecutive years of esophageal cancer death registration data) were compared to analyze the incidence of esophageal cancer Rate, the impact of mortality. Results 1. Anthracitic coal is rich in southeastern Shanxi Province in Shanxi Province, and there are many industrial and agricultural pollution sources. Two types of precursors of N-nitroso compounds in soil aeration zone, sewage and agricultural fertilizer are gradually collected in the rivers, and their concentrations gradually increase and pass Rivers, groundwater and other migrations to the middle and lower reaches. 2. The rivers originating in southeastern Shanxi Province consist of six rivers, Qingzhang River, Zhuozhang River, Qinhe River, Dan River, Qihe River and Wei River. Among them, the first five rivers flow into a bundled stream and Wei River flows in five rivers Of the downstream into a circular arc from the interception, excretion, so that the river flows to the Haihe River, southeast of Wei River are high incidence of esophageal cancer, into an irregular concentric distribution. 3, Jin Jiyu junction of the three provinces, the climate is semi-arid, mostly mountainous, hills, water scarce, residents have more canal diversion habits. 4, the greater the population effective pollution rate, the higher the mortality rate of esophageal cancer. Conclusions The high incidence of esophageal cancer at the junction of the Jin-Yu-Henan provinces and the southern section of the Taihang Mountains is related to rivers. Climatic types and amines, amide sources determine the effective concentration of two types of precursors. Rivers, artificial canal network of water is the carrier, determines the distribution of two types of precursors. The direct and indirect drinking water of the population and the number of irrigated canals determine the population mortality rate.