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[目的]总结嗅神经母细胞瘤的临床特点及其治疗。[方法]2000年至2008年治疗31例嗅神经母细胞瘤,Kadish分期:A期2例、B期16例、C期13例。采用单纯手术1例,30例综合治疗,其中11例加用辅助化疗。[结果]全组总的3年累积生存率为83.5%,5年累积生存率为60.7%;Kadish’s A期、B期和C期的5年累积生存率分别为100%、70.3%和40.4%(P=0.03)。晚期患者手术+放疗组、手术+放疗+化疗组的3年累积生存率分别为28.6%、50.0%。[结论]嗅神经母细胞瘤的预后与Kadish分期相关。手术加放疗的综合治疗是有效的治疗策略,晚期患者的辅助化疗是必要的。
[Objective] To summarize the clinical features and treatment of olfactory neuroblastoma. [Method] Twenty - one cases of olfactory neuroblastoma were treated from 2000 to 2008. The Kadish stage was 2 cases in stage A, 16 cases in stage B and 13 cases in stage C. Simple surgery in 1 case, 30 cases of comprehensive treatment, of which 11 cases plus adjuvant chemotherapy. [Results] The overall 3-year cumulative survival rate was 83.5% and the 5-year cumulative survival rate was 60.7%. The 5-year cumulative survival rates of Kadish’s A, B and C were 100%, 70.3% and 40.4% (P = 0.03). The 3-year cumulative survival rates of patients in advanced surgery + radiotherapy group, surgery + radiotherapy + chemotherapy group were 28.6% and 50.0% respectively. [Conclusion] The prognosis of olfactory neuroblastoma is related to Kadish staging. Combined surgery and radiotherapy is an effective treatment strategy, adjuvant chemotherapy in advanced patients is necessary.