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目的对2008年1月—2009年12月武汉大学人民医院就诊患者进行HBV、HCV、TP、HIV4种常见经血液传播病原体感染状况和流行因数进行分析,为有关部门制定血源性感染疾病预防控制决策提供参考资料。方法从2008年1月—2009年12月在武汉大学人民医院就诊患者及体检人群中随机抽取36710名患者,运用全自动免疫分析系统Abboti2000和ROCHE601对上述观察对象的HBV、HCV、HIV和梅毒的血清学标志物进行了定量分析,并运用描述性流行病学方法,采用SPSS11.0软件的“χ2检验”进行统计学数据分析。结果从2008年到2009年间HBV的感染率逐年下降(χ2=28.88,P<0.01),而HCV,TP和HIV的感染率逐年升高(P<0.01),在4种经血传播疾病病原体(HBV、HCV、TP和HIV)中合并2种或2种以上病原体感染的合并总感染率未见明显上升(P>0.05);在性别对比中,4种常见经血液传播病原体感染率在男性人群中明显高于女性(P<0.01);在年龄对比中,HBV感染率在≥35岁年龄组中明显高<35岁年龄组(P<0.01),而其他3种血液传播病原体感染率无年龄上的差异(P>0.05)。结论一些传统的经血传播病原体(HBV,HCV)的感染率在逐年下降,而性传播病原体(TP,HIV)感染率在逐年增加,其流行趋势不容乐观。
Objective To analyze the prevalence and epidemic factors of HBV, HCV, TP and HIV among the patients who were treated in People’s Hospital of Wuhan University from January 2008 to December 2009 and to make the prevention and control of blood-borne infection disease Decision-making to provide reference materials. Methods From January 2008 to December 2009, 36,710 patients were randomly selected from the patients and the physical examination group of People’s Hospital of Wuhan University. The immune system Abboti2000 and ROCHE601 were used to detect HBV, HCV, HIV and syphilis Serological markers were quantitatively analyzed and statistically analyzed using the “χ2 test” of SPSS11.0 using descriptive epidemiological methods. Results The infection rate of HBV decreased year by year from 2008 to 2009 (χ2 = 28.88, P <0.01), and the infection rates of HCV, TP and HIV increased year by year (P <0.01) , HCV, TP and HIV), no significant increase in the total combined infection rate was found between two or more pathogens (P> 0.05). In the sex comparison, the prevalence of four common blood borne pathogens in the male population (P <0.01). In age comparison, the HBV infection rate was significantly higher in 35-year-old age group than in 35-year-old age group (P <0.01), while the other three kinds of blood-borne pathogens had no age (P> 0.05). Conclusion The infection rates of some traditional blood-borne pathogens (HBV and HCV) are declining year by year. However, the prevalence of sexually transmitted pathogens (TP and HIV) is increasing year by year. The epidemic trend is not optimistic.