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目的:探讨慢性阻塞性肺病(COPD)患者血清IGF-Ⅱ水平的变化及其临床意义。方法:采用放射免疫分析测定60例COPD患者和30例非COPD患者的血清IGF-Ⅱ水平,并进行对照统计分析。结果:COPD组血清IGF-Ⅱ水平显著高于对照组(0.65±0.22μg/L vs 0.51±0.18μg/L;t=3.015;P<0.01),Ⅰ、Ⅱ、Ⅲ期COPD患者间IGF-Ⅱ水平无显著性差异(F=0.287,P>0.05),住院死亡组血清IGF-Ⅱ水平显著高于好转出院组(t=2.727,P<0.05)。结论:COPD患者血清IGF-Ⅱ显著升高,住院死亡组升高更明显。
Objective: To investigate the changes of serum IGF-Ⅱ level in patients with chronic obstructive pulmonary disease (COPD) and its clinical significance. Methods: Serum IGF-Ⅱ levels in 60 COPD patients and 30 non-COPD patients were determined by radioimmunoassay. Statistical analysis was performed. Results: The serum level of IGF-Ⅱ in COPD group was significantly higher than that in control group (0.65 ± 0.22μg / L vs 0.51 ± 0.18μg / L; t = 3.015; P <0.01) (F = 0.287, P> 0.05). The level of serum IGF-Ⅱ in hospitalized death group was significantly higher than that in discharged hospital (t = 2.727, P <0.05). Conclusion: Serum IGF-Ⅱ levels in patients with COPD were significantly higher than those in hospitalized patients.