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许多寄生虫感染,包括疟疾,伴有免疫抑制作用。反复发生因疟疾引起的免疫抑制可能是热带儿童细菌感染发病率高的原因和可能干扰免疫接种程序,也可能有其他远期作用,如容易患Burkitt氏淋巴瘤。作者认为此种免疫抑制作用若是时间短暂,则其意义不大,而如时间较长,临床上就相当重要。因此从患急性恶性疟疾的儿童,在其患病后的不同时间,用伤寒菌苗及流行性脑膜炎菌苗接种,观察其免疫应答。
Many parasitic infections, including malaria, are accompanied by immunosuppressive effects. Repeated immunosuppression due to malaria may be the reason for the high prevalence of bacterial infection in tropical children and may interfere with immunization procedures and may have other long-term effects such as predisposition to Burkitt’s lymphoma. The authors believe that such immunosuppression if time is short, it is not meaningful, but as time goes by, clinically important. Therefore, children with acute falciparum malaria were vaccinated with typhoid vaccine and epidemic meningitis vaccine at different times after their illness to observe their immune response.