[Objectives] By comparing D. chinensis polysaccharide granule with D. chinensis polysaccharide of direct use equivalent,it is determined if the dosage form could affect hepatoprotective effects and mechanisms of D. chinensis polysaccharide. [Methods] 50 SD rats are randomly divided into 5 groups: blank group,model group,biphenyl dimethylester positive group( 50 mg /( kg·d)),D. chinensis polysaccharide group( 200 mg /( kg·d)) and D. chinensis polysaccharide granule group( 700 mg /( kg·d),which is equivalent to 200 mg /( kg·d) of polysaccharide). Except blank group and model group,corresponding dosage of drug is irrigated to the stomach in other groups. After two weeks,except blank group,D-galactosamine( 400 mg / kg) is injected into abdominal cavity of each group to establish liver injury model of rat.After anaesthesia,blood is taken from abdominal aorta,and liver is collected and fixed by 4% paraformaldehyde. The levels of glutamic-pyruvic transaminase( ALT),AST,superoxide dismutase( SOD),glutathione peroxidase( GSH-PX),malonaldehyde( MDA),tumor necrosis factor-α( TNF-α),interleukin-1β( IL-1β) and interleukin-6( IL-6) in serum are detected,and microscopic observation of liver tissue pathological section is conducted. [Results]Compared with model group,the levels of ALT,AST,MDA,TNF-α,IL-1β and IL-6 in rat’s serum from D.chinensis polysaccharide group and D. chinensis polysaccharide granule group significantly decline,while SOD activity significantly rises. Pathological changes of liver tissue are improved significantly,and their curative effects are equivalent. [Conclusions]D. chinensis polysaccharide granule has significant protection role on acute liver injury of rat caused by D-galactosamine; its utilization convenience is showed while not declining its hepatoprotective effect. [Objectives] By comparing D. chinensis polysaccharide granule with D. chinensis polysaccharide of direct use equivalent, it is determined that the dosage form could affect hepatoprotective effects and mechanisms of D. chinensis polysaccharide. [Methods] 50 SD rats are divided into 5 groups: blank group, model group, biphenyl dimethylester positive group (50 mg / (kg · d)), D. chinensis polysaccharide group (200 mg / (kg · d) kg · d), which is equivalent to 200 mg / (kg · d) of polysaccharide. Except blank group and model group, corresponding dosage of drug is irrigated to the stomach in other groups. After two weeks, except blank group, D is injected into abdominal cavity of each group to establish liver injury model of rat. After anaesthesia, blood is taken from abdominal aorta, and liver is collected and fixed by 4% paraformaldehyde. The levels of glutamic- pyruvic transaminase (ALT), AST, superoxide dismutas (SOD), glutathione peroxidase (GSH-PX), malonaldehyde (MDA), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β) and interleukin-6 , and microscopic observation of liver tissue pathological section is conducted. [Results] Compared with model group, the levels of ALT, AST, MDA, TNF-α, IL-1β and IL-6 in rat’s serum from D. chinensis polysaccharide group and Pathological changes of liver tissue are more significantly, and their curative effects are equivalent. [Conclusions] D. chinensis polysaccharide granule has a significant protection role on acute liver injury of rat caused by D-galactosamine; its utilization convenience was showed while not declining its hepatoprotective effect.