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目的探讨植雅牙膏在甘露醇药物外渗中的护理效果及应用价值。方法选择我院2013年4月~2015年4月进行20%甘露醇静脉滴注时外渗的25名患者进行此次研究。本次研究采用随机数字表法,随机将患者分为实验组和对照组。实验组包含13名患者,对照组包含12名患者。实验组使用植雅牙膏直接均匀涂于甘露醇外渗处,对照组甘露醇外渗处给予常规方法处理,即50%硫酸镁热敷、0.5%的普鲁卡因液5~20ml或透明质酸50~250u局部封闭,仔细观察皮肤情况,统计静脉炎发生率以及询问患者是否疼痛。结果实验组皮肤损伤1例,其中皮肤红肿1例,皮肤坏死0例,皮肤溃烂0例。对照组皮肤损伤12例,其中皮肤红肿10例,皮肤坏死2例,皮肤溃烂0例。其中两组皮肤红肿比较有明显差别(P<0.05),两组皮肤坏死和皮肤溃烂比较无明显差别(P>0.05)。实验组静脉炎发生1例,对照组静脉炎发生2例,两组无明显差别(P>0.05)。处理一段时间后,实验组与对照组患者的疼痛人数分别为1例和10例,两组具有统计学意义(P<0.05)。结论植雅牙膏在甘露醇外渗中的护理效果很好,甚至优于常规处理方法,值得在临床上推广应用。
Objective To investigate the nursing effect and its application value of artificial toothpaste in mannitol extravasation. Methods Twenty-five patients with extravasation of 20% mannitol intravenously from April 2013 to April 2015 in our hospital were selected for this study. This study uses a random number table method, randomized patients into experimental group and control group. The experimental group consisted of 13 patients and the control group comprised 12 patients. In the experimental group, the plantarum toothpaste was applied directly to the extravasation of mannitol, while the control group mannitol extravasation was given conventional treatment, namely 50% magnesium sulfate hot compress, 0.5-20% procaine solution 5-20ml or hyaluronic acid 50 ~ 250u partially closed, carefully observe the skin condition, statistical phlebitis incidence and ask the patient whether the pain. Results 1 case of skin injury in experimental group, including skin irritation in 1 case, 0 cases of skin necrosis, skin ulceration in 0 cases. The control group had 12 cases of skin lesions, including 10 cases of skin irritation, 2 cases of skin necrosis and 0 cases of skin ulceration. There was obvious difference between the two groups (P <0.05). There was no significant difference between the two groups in skin necrosis and skin ulceration (P> 0.05). One case of phlebitis occurred in the experimental group and two cases of phlebitis in the control group. There was no significant difference between the two groups (P> 0.05). After a period of treatment, the number of pain patients in the experimental group and the control group were 1 and 10, respectively, with statistical significance (P <0.05). Conclusions The effect of UF toothpaste in mannitol extravasation is good, even better than the conventional treatment, which is worth popularizing in clinic.