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目的探讨继发性胶质母细胞瘤的MR表现。方法回顾性分析12例经病理证实的继发性胶质母细胞瘤的MR表现。结果 12例患者共发现16处复发病灶,其中12处经病理证实为胶质母细胞瘤,均表现出由低级别胶质瘤向胶质母细胞瘤恶性演变的过程;从低级别胶质瘤发展到胶质母细胞瘤的间隔时间为6个月~20年不等,平均为5.5年。复发病灶主要呈稍长T1、长T2信号,多数信号较为混杂,伴有明显的出血坏死(n=10)、囊变(n=6),复发瘤多位于原发灶2 cm范围内(n=11),增强扫描呈不均匀明显强化。结论继发性胶质母细胞瘤MR表现有一定特征,并且有较低级别胶质瘤术后多次复发的病史,结合影像学上明显恶性进展的表现,诊断继发性胶质母细胞瘤并不困难。
Objective To investigate the MR findings of secondary glioblastoma. Methods The MR findings of 12 patients with pathologically confirmed secondary glioblastoma were analyzed retrospectively. Results A total of 16 recurrent lesions were found in 12 patients. Twelve of them were confirmed as glioblastoma by pathology. All of them showed the malignant progression from low grade glioma to glioblastoma. From low grade glioma The development of glioblastoma interval of 6 months to 20 years, with an average of 5.5 years. Most of the recurrence lesions were slightly longer T1 and T2 signals. Most of the signals were mixed with obvious hemorrhage and necrosis (n = 10) and cystic change (n = 6) = 11), enhanced scan was uneven significantly enhanced. Conclusion MR has some characteristics of secondary glioblastoma, and there is a low-grade glioma recurrence after a number of recurrent history, combined with the imaging findings of malignant progression, the diagnosis of secondary glioblastoma Not difficult.