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目的观察间充质干细胞(MSC)对难治性慢性苯中毒是否存在治疗价值。方法以3例难治性慢性苯中毒患者为研究对象,将健康供者的MSC进行分离培养、扩增,再输注给患者,监测患者的白细胞、中性粒细胞、血红蛋白、血小板和不良反应等临床指征,进行临床评估。结果 3例难治性慢性苯中毒患者均有不同程度的疗效,其中1例达到临床治愈,且未出现明显不良反应。结论 MSC对难治性慢性苯中毒有潜在治疗价值。
Objective To observe the therapeutic value of mesenchymal stem cells (MSCs) on refractory chronic benzene poisoning. Methods Three patients with refractory chronic benzene poisoning were enrolled in this study. MSCs from healthy donors were isolated and cultured, expanded, and then infused into patients to monitor leukocytes, neutrophils, hemoglobin, platelets and adverse reactions Clinical indications, such as clinical evaluation. Results All 3 patients with refractory chronic benzene poisoning had different degrees of curative effect. One of them achieved clinical cure and no obvious adverse reactions occurred. Conclusion MSC have potential therapeutic value on refractory chronic benzene poisoning.