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目的:探讨急性有机磷农药中毒(AOPP)患者血清心肌肌钙蛋白-I(CTnⅠ)和胱抑素-C(Cys-C)的改变及临床价值。方法:采用酶连免疫吸附反应(ELISA)法和全自动生化分析仪检测109例AOPP患者的血清CTnⅠ浓度和Cys-C浓度,并将100例健康体检者作为对照组进行比较。结果:AOPP组中毒后1 d、3 d、5 d时的血清CTnⅠ和Cys-C水平显著高于对照组,相比较有显著性差异(P<0.05);血清CTnⅠ和Cys-C水平随着中毒程度加重而升高。结论:AOPP患者的病情与血清CTnⅠ和Cys-C水平的变化密切相关,AOPP患者血清CTnⅠ和Cys-C水平的升高对心肌和肾脏受损具有重要的诊断意义。
Objective: To investigate the changes and clinical value of serum cardiac troponin-I (CTnⅠ) and cystatin-C (Cys-C) in patients with acute organophosphorus pesticide poisoning (AOPP). Methods: Serum CTn Ⅰ concentration and Cys-C concentration in 109 patients with AOPP were detected by enzyme-linked immunosorbent assay (ELISA) and automated biochemical analyzer. 100 healthy subjects were compared as control group. Results: The levels of CTnⅠ and Cys-C in serum of the AOPP group were significantly higher than those of the control group on the 1st, 3rd and 5th days (P <0.05), and the levels of CTnⅠ and Cys-C Toxicity increased and increased. CONCLUSIONS: The condition of AOPP patients is closely related to the changes of serum CTnⅠ and Cys-C levels. The elevated serum levels of CTnⅠ and Cys-C in AOPP patients have important diagnostic significance for myocardial and renal damage.