采用人血T淋巴细胞EA花结形成试验,以及小鼠同种异体植皮及耳后心脏移植等法,观察了蝙蝠蛾拟青霉人工发酵培养物(简称拟青霉)对人体细胞免疫以及小鼠组织移植抗排斥反应的影响。结果证明拟青霉能显著抑制EA花结形成率,延长小鼠移植皮片及移植心脏的存活期,对骨髓、脾脏均无影响。对胸腺呈可复性的抑制作用,毒性极低,提示拟青霉对T细胞系统具有特异的免疫抑制作用,呈现较好的抗排斥反应。 Using human blood T-lymphocyte EA rosette formation test, mouse allograft skin transplantation and post-auricular heart transplantation, the artificial fermentation culture of Paecilomyces bat-moth (Paecillus imbru) was observed for human cell immunity and Effects of Murine Tissue Transplantation on Anti-rejection The results showed that Paecilomyces can significantly inhibit the rate of EA rose formation, prolong the survival period of mouse skin grafts and transplanted hearts, and had no effect on bone marrow and spleen. The thymus was reversible and the toxicity was extremely low, suggesting that Paecilomyces had a specific immunosuppressive effect on the T cell system and showed a good anti-rejection response.