论文部分内容阅读
目的:重点研究抗菌药物不良反应发生的规律、特点及其产生因素,促进临床用药安全。方法:对我院2010年1月至2011年6月期间各科室上报的临床使用抗菌药致不良反应报告进行回顾性分析与探讨。结果:抗菌药致不良反应报告中,多为用药当天发生。头孢菌素类药物所引发的不良反应在所有抗感染药物中占首位。抗菌药引起的不良反应累及到多个器官及系统,首先是对人体皮肤及其附件造成的损害,其次是对神经系统和消化系统的损害。另外对某些机体的损害较为严重,如对肾功能、肝功能的损害及出现过敏性休克等。160例抗菌药致不良反应报告中,91例治愈,为59.80%,69例好转,为38.24%,另有10例留下后遗症,为1.96%。结论:抗菌药致不良反应具有后果的严重性,为确保抗菌药物的用药安全,要结合多方面因素合理选择抗菌药物及其给药方式,最大程度上降低不良反应的发生率、提高疗效及减缓或减少产生细菌耐药性。
Objective: To study the regularity, characteristics and causes of adverse reactions of antimicrobial agents and to promote the safety of clinical medication. Methods: A retrospective analysis and discussion were made on the reports of adverse reactions caused by antibiotics in clinical departments reported from January 2010 to June 2011 in our hospital. Results: Antibacterial agents caused adverse reactions in the report, the majority occurred on the day of medication. Adverse reactions caused by cephalosporins in all anti-infective drugs in the first place. Adverse reactions caused by antimicrobial agents are involved in multiple organs and systems, primarily damage to human skin and its appendages, followed by damage to the nervous system and digestive system. In addition to some of the more serious damage to the body, such as renal function, liver damage and the emergence of anaphylactic shock. Of 160 cases of adverse reactions caused by antibiotics, 91 cases were cured, 59.80%, 69 cases improved, 38.24%, and the other 10 cases left sequelae, 1.96%. Conclusion: The adverse reactions caused by antimicrobial agents have serious consequences. To ensure the safety of antimicrobial drugs, rational combination of antimicrobial agents and their administration should be taken to minimize the incidence of adverse reactions, improve the curative effect and slow down Or reduce the production of bacterial resistance.