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目的分析孕产妇感染产单核李斯特菌的临床特点,为临床合理用药提供理论依据。方法回顾分析北京妇产医院2006年1月-2013年12月临床孕产妇及其新生儿感染产单核李斯特菌的情况,并进行药物敏感试验。结果妊娠期妇女是李斯特菌感染的高发人群;新生儿李斯特菌病多数为早产儿(包括晚期流产儿)。其药敏试验显示目前对青霉素、氨苄西邻均敏感,未出现耐药菌株。结论产单核细胞李斯特菌对人类有很强的致病性,尤其对免疫力低下的孕产妇,积极治疗该菌引起的感染对有效减少孕产妇感染率、降低围产儿死亡率,具有非常重要的意义。
Objective To analyze the clinical features of Listeria monocytogenes infected by maternal infection and provide a theoretical basis for clinical rational drug use. Methods A retrospective analysis of clinical maternal and neonatal infection with Listeria monocytogenes from Beijing Maternity and Child Hospital from January 2006 to December 2013 was conducted and drug susceptibility testing was conducted. Results Pregnant women were high risk of Listeria infection; most of the neonatal listeriosis was premature (including late abortion). The drug sensitivity test shows that the current penicillin, ampicillin are sensitive, no drug-resistant strains. Conclusion Listeria monocytogenes has a strong pathogenicity to humans, especially for immunocompromised pregnant women. Active treatment of the infections caused by this bacterium can effectively reduce the rate of maternal infection and reduce perinatal mortality. Significance.