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目的研究抵抗素在老年肥胖患者及健康对照血浆中的平均水平,探讨抵抗素与肥胖及胰岛素抵抗的关系。方法竞争性酶联免疫吸附法检测43例老年肥胖患者及41例对照的空腹血浆抵抗素水平,测量身高、体重、腰围、臀围,计算体重指数(BMI)及腰臀比(WHR),口服葡萄糖耐量试验(OGTT)测定空腹血浆葡萄糖浓度及胰岛素浓度,计算胰岛素敏感指数(ISI)。结果空腹血浆抵抗素与BMI呈正相关(r=0.23,P<0.05),与胰岛素呈负相关(r=-0.34,P<0.05),与ISI呈负相关(r=-0.31,P<0.05),未发现与血脂、年龄、性别及WHR之间的相关性。结论人类血浆抵抗素与肥胖及胰岛素抵抗相关。
Objective To study the average level of resistin in elderly obese patients and healthy controls, and to explore the relationship between resistin and obesity and insulin resistance. Methods Fasting plasma resistin levels were measured in 43 elderly obese patients and 41 controls by competitive enzyme-linked immunosorbent assay. Height, weight, waist circumference, hip circumference, body mass index (BMI) and WHR were measured. Glucose tolerance test (OGTT) Determination of fasting plasma glucose and insulin concentrations, calculated insulin sensitivity index (ISI). Results Fasting plasma resistin was positively correlated with BMI (r = 0.23, P <0.05) and negatively correlated with insulin (r = -0.34, P <0.05) No correlation was found with blood lipids, age, sex and WHR. Conclusion Human plasma resistin is associated with obesity and insulin resistance.