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目的探讨人微小病毒B19(HPVB19)感染与儿童特发性血小板减少性紫癜(ITP)发病的关系及其临床意义。方法采用聚合酶链反应(PCR)对30例ITP患儿和20例健康儿童的血清标本进行检测,并用酶联免疫法(ELISA)检测血小板相关抗体。结果病毒感染阳性患儿的血小板相关抗体PAIgG、PAIgA明显高于病毒感染阴性患儿(P均<0.05);ITP组患儿血清中HPVB19-DNA阳性率40.0%(12/30)显著高于对照组(0)(P<0.05)。结论 ITP患儿血清中HPVB19-DNA阳性率高,病毒感染可导致血小板相关抗体升高而致血小板减少。
Objective To investigate the relationship between the infection of human parvovirus B19 (HPVB19) and the incidence of idiopathic thrombocytopenic purpura (ITP) in children and its clinical significance. Methods Serum samples from 30 children with ITP and 20 healthy children were detected by polymerase chain reaction (PCR) and antibodies against platelet were detected by enzyme-linked immunosorbent assay (ELISA). Results The platelet-associated antibodies PAIgG and PAIgA in children with virus-positive infection were significantly higher than those in children with negative virus infection (all P <0.05). The positive rate of HPV B19-DNA in serum of ITP group was significantly higher than that of control (40.0%, 12/30) Group (0) (P <0.05). Conclusions The positive rate of HPVB19-DNA in the serum of ITP children is high, and the virus infection can lead to the increase of platelet-associated antibodies and the decrease of thrombocytopenia.