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AIM: To establish a model of cerebral infarction in order to study the interventional treatment.METHODS: An improved 3.0F SP Cobra catheter was introduced to the internal carotid artery by puncturing the femoral artery. After internal carotid arteriography thrombus was injected to embolize its MCA. 3 hours later, clinic observe and computed tomography was examined to analyze results.RESULTS: Clinic observation confirmed that the rabbit had some nerve defect symptoms and CT exam proved cerebral infarction.CONCLUSION: This technique is convenient for application and the model can meet the standard of study of clinical interventional treatment.