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目的探讨二氢吡啶类钙拮抗剂治疗原发性高血压的疗效。方法将68例高血压患者随机分成硝苯地平组(A 组)、硝苯地平控释片组(B 组)、司乐平缓释片组(C)和硝苯地平并用卡托普利组(D 组),每组17例。分别于治疗后3 d、1周,每周一次血压至4周结束,同时注意副反应。结果 4组中每组治疗前与治疗后收缩压与舒张压差异均有显著性意义,P<0.05,总有效率各组间比较无显著性差异,P>0.05。结论二氢吡啶类钙拮抗剂可选择性作用于血管平滑肌的钙通道扩张周围动脉,减少外周血管阻力,从而降低血压,而联合卡托普利的总有效率均高于任一单一剂型的二氯吡啶类钙拮抗剂。
Objective To investigate the therapeutic effect of dihydropyridine calcium antagonists on essential hypertension. Methods Sixty-eight patients with hypertension were randomly divided into nifedipine group (A group), nifedipine controlled-release group (B group), simvastatin sustained-release tablets group (C) and nifedipine with captopril group D group), 17 cases in each group. Respectively 3 days after treatment, 1 week, once a week blood pressure to the end of 4 weeks, while paying attention to side effects. Results There were significant differences in systolic and diastolic blood pressures before and after treatment in each of the four groups, P <0.05. There was no significant difference in total effective rate between the two groups (P> 0.05). Conclusion Dihydropyridine calcium antagonists can selectively act on calcium channels in vascular smooth muscle to dilate peripheral arteries and reduce peripheral vascular resistance, thus lowering blood pressure. However, the total effective rate of combined captopril is higher than that of any single dosage form Chloropyridines Calcium antagonists.