普萘洛尔(propranolol)为β-受体阻滞剂,临床上被广泛用于治疗心律失常和心绞痛,有效浓度为50～150 ng/ml,也有报道为20～50 ng/ml。近来有报道口服普萘洛尔治疗血管性偏头痛。由于普萘洛尔的首过肝脏作用,生物利用度的个体差异大,有效剂量的变化也大。临床上希望通过测定普萘洛尔血药浓度,进行药代动力学过程的研究,结合临床指征,建立合理的用药方案。 Propranolol, a beta-blocker, is clinically widely used in the treatment of arrhythmias and angina pectoris. The effective concentration is 50-150 ng / ml, which is also reported as 20-50 ng / ml. It has recently been reported that oral propranolol is used to treat vascular migraine. Due to the first-pass hepatic effect of propranolol, individual differences in bioavailability are large and changes in effective doses are also large. Clinical hope through the determination of propranolol plasma concentration, the pharmacokinetic process of research, combined with clinical indications, the establishment of a reasonable drug program.