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目的基于大鼠尾吊实验,研究模拟微重力对关节软骨组织力学特性的影响。方法通过14 d的尾吊实验建立模拟微重力作用的大鼠模型,获得12块后肢大腿骨关节处软骨样本,运用高频超声测量技术获取大鼠关节软骨特定位置因自由膨胀引起的组织应变,基于三相模型估计软骨组织的轴向弹性模量,并比较尾吊组和对照组大鼠关节软骨的力学特性。结果尾吊组大鼠后肢特定测量位置处软骨厚度的平均值略小于对照组,但差异不显著;尾吊组大鼠特定位置关节软骨组织的平均轴向弹性模量为(5.05±2.98)MPa,小于对照组((6.31±3.37)MPa),两者存在着显著差异(P<0.05)。结论微重力环境会影响关节软骨组织的力学特性,本研究结果为人类长期的太空活动提供参考信息。
OBJECTIVE: To study the effect of simulated microgravity on the mechanical properties of articular cartilage tissue based on rat tail suspension test. Methods Rat model of simulated microgravity was established by 14-day tail suspension test. Twelve cartilage samples of hind limbs were obtained. High-frequency ultrasound was used to acquire the tissue strain caused by free expansion of specific position of rat articular cartilage. The axial elastic modulus of the cartilage tissue was estimated based on the three-phase model, and the mechanical properties of the cartilage of the tail-suspension group and the control group were compared. Results The mean value of cartilage thickness at the specific position of tail hindlimb in tail suspension group was slightly less than that in control group, but the difference was not significant. The average axial elastic modulus of cartilage in tail suspension group was (5.05 ± 2.98) MPa (6.31 ± 3.37) MPa, which was significantly different between the two groups (P <0.05). Conclusion Microgravity environment will affect the mechanical properties of articular cartilage tissue, the results of this study provide reference information for human long-term space activities.