论文部分内容阅读
喹诺酮类药物是一类化学合成药物,由于其具有较强抗菌活性,临床上已广泛用于各种细菌性感染。随着喹诺酮类药物在临床上越来越广泛的应用,喹诺酮类药物的耐药也逐渐上升。已知细菌对喹诺酮类药物的主要耐药机制为:①靶位基因Ⅱ型拓扑异构酶即DNA回旋酶基因(gyrA和gyrB)和拓扑异构酶Ⅳ基因(parC和parE)突变;②细菌膜通透性的降低和膜上药物主动外排泵的激活;③质粒上qnr基因介导细菌对喹诺酮类耐药。
Quinolones are a class of chemosynthetic drugs. Because of their strong antibacterial activity, quinolones have been widely used clinically for various bacterial infections. With the increasing use of quinolones in clinical practice, quinolone resistance has also gradually risen. Known bacteria quinolones major resistance mechanisms are: ① target gene type Ⅱ topoisomerase DNA gyrase gyrA and gyrB genes and topoisomerase Ⅳ gene (parC and parE) mutations; ② bacteria Membrane permeability and the membrane active drug efflux pump activation; ③ plasmid qnr gene mediated quinolone resistance of bacteria.