肾病综合征(NS)儿童部分表现为糖皮质激素(GC)抵抗,治疗非常棘手,预后不容乐观。NS是一种由多病因引起的综合征,因此激素抵抗的原因也是多种多样的。有些NS本质上不是由免疫介导的,免疫异常在NS发生中的作用也不同。现从GC作用机制各环节阐述GC抵抗的发生机制,并介绍激素抵抗型NS的治疗策略。 Part of children with nephrotic syndrome (NS) show glucocorticoid (GC) resistance, treatment is very difficult, the prognosis is not optimistic. NS is a syndrome caused by multiple etiologies, so hormone resistance is also varied. Some NSs are not intrinsically mediated by immunity, and immune dysfunction plays a different role in the development of NS. Now from the mechanism of GC mechanism of all aspects of the mechanism of GC resistance, and introduce hormone-resistant NS treatment strategy.