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为了解非典型抗精神病药物的不良作用,检索国外有关文献中临床试验的数据,比较典型与非典型抗精神病药物之间,及各种非典型抗精神病药物之间不良作用的差异。非典型药物致锥体外系综合症(EPS)、迟发性运动障碍(TD)发生率均低于典型药物;一般非典型药物血中催乳激素增高低于典型药物。其他不良作用的发生率可能与典型药物相同。非典型药物引起患者体重增加是值得关注的问题,在非典型药物之间,不良作用发生的类型、严重程度均有差异,临床医生选择用药应个体化。
To understand the adverse effects of atypical antipsychotics, data from clinical trials in relevant foreign literature were retrieved to compare the adverse effects of typical and atypical antipsychotics and various atypical antipsychotics. The incidence of atypical extrapyramidal syndrome (EPS) and tardive dyskinesia (TD) in atypical drugs was lower than that of typical drugs. The increase of serum prolactin in common atypical drugs was lower than that of typical drugs. The incidence of other adverse effects may be the same as typical drugs. Atypical drugs cause weight gain in patients is a cause for concern, between atypical drugs, adverse effects occur in the type and severity are different, clinicians choose the drug should be individualized.