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目的 了解抗Ⅱ型胶原抗体在类风湿关节炎 (RA)中的临床意义。方法 以改进的酶联免疫吸附法 (ELISA)检测 179例RA患者和 171例其他风湿病患者的血清IgG型抗天然及抗变性Ⅱ型胶原抗体水平。结果 RA患者抗天然和抗变性Ⅱ型胶原抗体阳性率各为 2 2 3%和 36 9% ,早期RA患者各为 30 0 %和 36 7%。其他风湿病患者中各为 3 5 %和 31 6 % ,健康人二者均为2 5 %。抗天然Ⅱ型胶原抗体阳性RA患者类风湿因子检出率、患者对病情活动性评价高于阴性组(P <0 0 5 )。抗变性Ⅱ型胶原抗体和抗天然Ⅱ型胶原抗体同时阳性RA患者的CRP平均水平较高。结论 抗天然Ⅱ型胶原抗体可以作为RA的一个辅助诊断指标。抗天然与抗变性Ⅱ型胶原抗体的检测有助于判断RA病情活动性
Objective To understand the clinical significance of anti-type Ⅱ collagen antibody in rheumatoid arthritis (RA). Methods Serum IgG anti-native and anti-atypical type Ⅱ collagen antibodies were detected in 179 patients with RA and 171 patients with other rheumatic diseases by modified enzyme-linked immunosorbent assay (ELISA). Results The positive rate of anti-natural and anti-atypical type Ⅱ collagen antibodies in RA patients was 223% and 369%, respectively. The incidence of RA was 30 0% and 36 7% respectively in RA patients. Other rheumatism patients were 35% and 31 6%, respectively, and healthy persons were 25%. The detection rate of rheumatoid factor in RA patients with anti-natural type II collagen antibody was higher than that in the negative group (P <0.05). The average level of CRP in RA patients with both anti-atypical type II collagen antibodies and anti-natural type II collagen antibodies was high. Conclusion Anti-type Ⅱ collagen antibody can be used as an auxiliary diagnosis of RA. Detection of anti-natural and anti-atypical type II collagen antibodies can help determine the activity of RA