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目的探讨克罗米芬兴奋试验(CCT)在不孕妇女中预测卵巢储备功能的作用。方法对2001年1月至2005年2月就诊于广东省妇幼保健院的666例不孕症患者作为研究对象,分为A组(≥35岁)461例为高龄组,B组(<35岁)205例为低龄组,另取156例年龄<35岁、非女方不孕原因者作为对照组,对三组受试者进行CCT。结果CCT异常发生率A组、B组及对照组分别为27.76%、34.14%、2.56%,A组及B组与对照组比较差异均有非常显著性意义(P<0.01)。基础卵泡刺激素(FSH)<10IU/L、雌二醇(E2)<180pmol/L的不孕患者CCT异常发生率分别为17.46%、24.19%,均明显低于FSH≥10IU/L、E2≥180pmol/L患者的64.19%及39.4%(P<0.01)。结论CCT预测卵巢储备功能较基础FSH更敏感,CCT可作为常规了解卵巢储备功能的一项检测方法。
Objective To investigate the effect of clomiphene citrate excitatory test (CCT) on the prediction of ovarian reserve in infertile women. Methods A total of 666 cases of infertility patients who visited Guangdong Maternal and Child Health Hospital from January 2001 to February 2005 were divided into group A (46 years old ≥35 years), elderly group B (aged 35 years ) 205 cases of younger age group, another 156 cases of age <35 years old, non-female infertility as a control group, the three groups of subjects CCT. Results The abnormal incidence of CCT was 27.76%, 34.14% and 2.56% in group A, group B and control group, respectively. There was significant difference between group A and group B and control group (P <0.01). The incidence of CCT abnormalities in infertile patients with basal follicle stimulating hormone (FSH) <10IU / L and estradiol (E2) <180pmol / L were 17.46% and 24.19%, respectively, which were significantly lower than those with FSH≥10IU / L and E2≥ 64.19% and 39.4% of 180 pmol / L patients (P <0.01). Conclusion CCT predicts ovarian reserve function is more sensitive than basic FSH, and CCT may be used as a routine method to detect ovarian reserve function.