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目的 :研究进展期不能手术或手术后复发胃癌用榄香烯超液化栓塞乳剂介入治疗的疗效及适用性。方法 :对 6 8例进展期胃癌患者经超选择胃左动脉或肠系膜上动脉、腹腔动脉插管 2 96人次 ,用ELF、ELP或EAP方案灌注化疗后 ,再用 4:1比例的碘化油、榄香烯、MMC“泵法”配制的超液化乳剂栓塞 ,以治疗前后血管造影表现、GI、CT作为评价疗效的客观指标 ,治疗间隔时间 2～ 4月。观察肿瘤缩小率、栓塞剂滞留情况、生存时间和生存率及病理组织学变化。结果 :1年生存率为 6 3 .2 %、2年为 2 9.4% ,3年为 7.45 % ,肝转移和非肝转移的平均生存期为 9.6月和 15 .6月 ,肿瘤缩小率 6 4.8% ,均高于其它介入治疗或化疗。结论 :使用榄香烯超液化栓塞乳剂介入治疗进展期不能手术胃癌是一个有希望的治疗方法
Objective: To investigate the efficacy and applicability of interventional therapy with elemene hyper-liquefaction embolization for patients with advanced gastric cancer who cannot undergo surgery or relapse after surgery. METHODS: Sixty-eight patients with advanced gastric cancer were treated with superselective left gastric artery or superior mesenteric artery and celiac artery catheterization. After infusion chemotherapy with ELF, ELP, or EAP protocol, a 4:1 ratio of iodized oil was used. Ephedrine, MMC “pump method” prepared by the super-liquefaction emulsion embolism, before and after treatment angiographic performance, GI, CT as an objective indicator of evaluation of efficacy, treatment interval 2 April. Observed tumor shrinkage, embolic agent retention, survival time and survival rate and histopathological changes. Results: The 1-year survival rate was 63. 2%, 2.4% in 2 years, and 7.45 % in 3 years. The average survival period of liver metastasis and non-hepatic metastasis was 9.6 months and 15. 6 months. The tumor reduction rate was 64.8. % are higher than other interventions or chemotherapy. Conclusion: The use of elemene-based liquefaction embolization cream to treat advanced gastric cancer without intervention is a promising treatment