不少研究资料已证明神经肽在鼻炎的发病和临床症状上有重要作用,对啮齿类动物进行的试验证实反复应用辣椒辣素(capsaicin)进行鼻内激发可以收到快速减敏的效果。对鼻分泌过多的患者进行的辣椒辣素局部治疗表明经过反复鼻内激发后,鼻分泌减少,临床症状减轻。有一个试验证实5天的治疗可使症状缓解30～40天;另一个资料表明在4名患者中,5周的治疗导致12个月的症状缓解。介绍了Lacroix等的治疗方法:将辣椒辣素溶于70%乙醇,鼻粘膜可卡因麻醉,然后局部用药。对象为慢性非变应性鼻炎患者和健康志愿者。用鼻粘膜活检降钙素基因相关肽(cal- Many studies have shown that neuropeptides play an important role in the pathogenesis and clinical symptoms of rhinitis. Experiments on rodents have confirmed that repeated administration of capsaicin for intranasal stimulation can achieve rapid desensitization. Topical treatment of capsaicin in patients with excessive nasal secretions indicates that nasal secretion is reduced and clinical symptoms are relieved after repeated intranasal challenge. One trial confirmed that 5 days of treatment relieved the symptoms 30 to 40 days and another showed that 5 weeks of treatment resulted in 12 months of symptom relief in 4 patients. Introduced Lacroix and other treatment methods: Capsaicin dissolved in 70% ethanol, nasal mucosa cocaine anesthesia, and then topical. Subjects are chronic non-allergic rhinitis patients and healthy volunteers. Nasal mucosa biopsy calcitonin gene-related peptide (cal-