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目的:探讨卵巢上皮性肿瘤组织中P-EphA2的表达及其与临床病理因素的关系。方法:采用免疫组织化学Sp法检测82例卵巢上皮性肿瘤及24例正常卵巢组织中P-EphA2的表达情况。结果:在正常卵巢、卵巢上皮性良性肿瘤和卵巢恶性上皮性肿瘤组织中,P-EphA2蛋白的阳性表达率分别为100%、79.31%、26.9%,差异有统计学意义(P<0.05);卵巢恶性肿瘤中P-EphA2的表达与卵巢恶性上皮性肿瘤FIGO分期有关,差异有统计学意义(P<0.05),而与组织学分级、组织学类型、淋巴结转移、患者年龄无关。结论:P-EphA2与卵巢上皮性肿瘤的良恶性有关,在恶性肿瘤中,P-EphA2的表达显著降低,其表达与卵巢恶性肿瘤的FIGO分期相关。P-EphA2在卵巢上皮性恶性肿瘤中的低表达可以作为卵巢上皮性恶性肿瘤的诊断指标,可能成为新的卵巢癌诊断参考指标之一。
Objective: To investigate the expression of P-EphA2 in ovarian epithelial tumor and its relationship with clinicopathological factors. Methods: Immunohistochemical SP method was used to detect the expression of P-EphA2 in 82 cases of ovarian epithelial tumor and 24 cases of normal ovarian tissue. Results: The positive rates of P - EphA2 protein in normal ovarian epithelial ovarian cancer and ovarian epithelial tumor tissues were 100%, 79.31% and 26.9%, respectively, with statistical significance (P <0.05). The expression of P-EphA2 in ovarian cancer was correlated with the FIGO staging of ovarian malignant epithelial tumor (P <0.05), but not with histological grade, histological type, lymph node metastasis and patient’s age. Conclusion: P-EphA2 is associated with benign and malignant ovarian epithelial tumors. The expression of P-EphA2 in malignant tumors is significantly lower than that in ovarian malignant tumors. Low expression of P-EphA2 in ovarian epithelial malignancies can be used as a diagnostic indicator of epithelial ovarian cancer, which may become one of the new reference indexes for the diagnosis of ovarian cancer.