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作者旨在测定贮存于4、22或32℃31天的0.1和ling/ml与5%葡萄糖或0.9%氯化钠注射液的配伍稳定性.将0.l和limg/ml紫杉醇与5%葡萄糖或0.9%氯化钠注射液分别混合置于150ml袋中,贮存于4、22或32℃,试样一式三份,制备后立即和在1、3、5和7天从每袋中取样,用HPLC法测定,紫杉醇的浓度至少要保持在初始浓度的90%以上则认为稳定.并立即和在1、3、5、7、14和31天从每袋中取样,用比浊计和目测检查其物理配伍性.
The authors aimed to determine the compatibility stability of 0.1 and ling / ml with 5% glucose or 0.9% sodium chloride injection stored for 31 days at 4, 22 or 32 ° C. 0.1 and limg / ml paclitaxel were mixed with 5% glucose Or 0.9% Sodium Chloride Injection were separately placed in 150 ml bags, stored at 4, 22 or 32 ° C, samples were taken in triplicate and samples were taken from each bag immediately and 1, 3, 5 and 7 days after preparation, The concentration of paclitaxel was determined to be stable at least above 90% of its initial concentration as determined by HPLC and samples were taken from each bag immediately and on days 1, 3, 5, 7, 14 and 31 with a nephelometer and visual inspection Check its physical compatibility.