血管内皮细胞功能障碍在慢性非传染性疾病发病中的病理作用

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目的 血管内皮细胞是机体最大的内分泌组织细胞,位于血流与血管壁之间,将血液与血管壁分离开来.血管内皮细胞通过合成和释放多种内皮源性舒张因子和收缩因子在调节血管张力方面发挥着重要作用.此外,内皮细胞在维持抗凝/促凝平衡、血管生成、内分泌以及炎症和免疫中的作用也越来越被重视.越来越多的证据表明,血管内皮细胞功能对血管内稳态的维持至关重要,血管内皮细胞功能障碍是与血管收缩、血栓形成和炎症状态有关的各种微血管病变相关疾病的共同标志.本文主要就血管内皮细胞的结构和功能,以及功能障碍在心血管疾病、糖尿病并发症、慢性肾病等慢性非传染性疾病中的作用进行综述.
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