目的探讨妊娠期急性脂肪肝(AFLP)的临床特点,以利早期诊断和治疗。方法对我院自1992年1月～2005年12月收治的8例AFLP患者的临床资料进行回顾性分析。结果AFLP的临床表现以肝损害为主伴多器官功能受损,实验室检查符合“六高三低”表现。孕产妇治愈2例,死亡6例,死亡率75%,围生儿中,存活4例,死亡4例。结论早期诊断后及时终止妊娠,能明显改善母儿愈后,提高母儿生存率。 Objective To investigate the clinical features of acute fatty liver of pregnancy (AFLP) in order to facilitate the early diagnosis and treatment. Methods The clinical data of 8 AFLP patients admitted to our hospital from January 1992 to December 2005 were analyzed retrospectively. Results The clinical manifestations of AFLP were mainly liver damage with multiple organ dysfunction, laboratory tests in line with “six high, three low ” performance. Maternal cure in 2 cases, 6 cases of death, the mortality rate was 75%, 4 cases of perinatal survival, 4 cases of death. Conclusion Early termination of pregnancy after early diagnosis can significantly improve maternal and child after the increase of maternal and child survival.