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目的:探讨纤维环穿刺诱导椎间盘退变动物模型围手术期应对策略的可行性。方法:健康新西兰大白兔80只,随机分为4组,青霉素禁食组(A组),青霉素不禁食组(B组),非青霉素禁食组(C组),非青霉素不禁食组(D组)。用持针器夹持18G皮肤穿刺针从左前外侧刺入L3/4、L4/5、L5/6椎间盘的纤维环,深度控制在5mm。术后按照分组方法饲养,观察各组术后1周的预后情况。结果:围手术期不予特殊饮食管理的B、D组均出现较多肠梗阻,同时出现总计3只死亡,而A、C组出现肠梗阻只数显著少于另外2组(P<0.05),且无死亡。使用抗生素组与不使用抗生素组对术后切口感染坏死情况的发生无统计学差异。结论:纤维环穿刺诱导椎间盘退变动物模型围手术期的应对策略中,术前、术后的饮食管理可达到降低肠梗阻率,减少死亡率,从而降低研究成本的目的,而术后抗生素的使用与否并不影响预后。
Objective: To investigate the feasibility of perioperative strategies in the animal model of disc degeneration induced by fibrocentesis. Methods: Eighty healthy New Zealand white rabbits were randomly divided into 4 groups: penicillin fasting group (group A), penicillin non-fasting group (group B), non-penicillin fasting group (group C) (Group D). The 18G skin puncture needle was inserted into the L3 / 4, L4 / 5 and L5 / 6 intervertebral disc annulus fibrosus from the left anterolateral and the depth was controlled at 5mm. Postoperatively according to grouping method, observe the prognosis of each group after 1 week. Results: A total of 3 intestinal obstruction occurred in group B and group D without any special diet during perioperative period, while intestinal obstruction in group A and C was significantly less than that in other two groups (P <0.05) , And no death. There was no significant difference in the incidence of postoperative infection necrosis between antibiotic group and non-antibiotic group. CONCLUSION: In the perioperative strategy of animal model of intervertebral disc degeneration induced by pericyte puncture, preoperative and postoperative diet management can reduce the rate of intestinal obstruction and reduce mortality, thus reducing the study cost. However, postoperative antibiotic Use or not does not affect the prognosis.