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目的检测类风湿关节炎(RA)患者血清中的抗环瓜氨酸肽抗体(CCP)及类风湿因子(RF),探讨其临床应用价值。方法用ELISA法检测了74例RA、45例非RA及50例正常人体内的CCP,同时用速率散射比浊法定量测定了RF及C反应蛋白(CRP)。结果 CCP的敏感性为64.9%,特异性为97.9%,阳性预测值为96.0%,阴性预测值为78.2%;而RF的敏感性为86.5%,特异性为85.3%,阳性预测值为82.1%,阴性预测值为89.0%。CCP与RF及CRP结果间无相关性。结论将CCP与RF联合检测用于RA的诊断具有重要价值。
Objective To detect anti-cyclic citrullinated peptide antibody (CCP) and rheumatoid factor (RF) in the serum of patients with rheumatoid arthritis (RA) and explore its clinical value. Methods CCP was detected by ELISA in 74 cases of RA, 45 cases of non-RA and 50 cases of normal persons. The RF and C-reactive protein (CRP) were quantitatively determined by rate nephelometry. Results The sensitivity of CCP was 64.9%, the specificity was 97.9%, the positive predictive value was 96.0%, the negative predictive value was 78.2%; while the sensitivity of RF was 86.5%, the specificity was 85.3%, the positive predictive value was 82.1% , Negative predictive value of 89.0%. No correlation between CCP and RF and CRP results. Conclusion The combination of CCP and RF in the diagnosis of RA is of great value.